Resveratrol, the red wine antioxidant that is known to offer wonderful solutions for your skin care, has also shown to activate an ancient stress response mechanism in your cells that allow them to guard themselves against DNA damage. Vine Vera came across a study that was conducted by the scientists from the Scripps Research Institute, which explained the health benefits that have attributed to Resveratrol, a compound that is found in the skin of red grapes and in red wine.
According to the study, lower levels of Resveratrol are more than sufficient to activate the stress response system in your skin. These levels are far lower than what was previously believed and the study itself helps to clear up a lot of mystery that initially surrounded Resveratrol and the benefits that it had to offer.
Vine Vera found this study published in the Nature Journal. The study re-builds on the recent research conducted by the Scripps Research Institute, which had discovered the existence of unique mechanisms that were associated with the enzymes being studied. Resveratrol has already been attributed to the famous “French Paradox”. According to this paradox, people in France enjoy a lower cardiovascular disease rate despite their high saturated fat diet. One of the many problems in discovering the benefits that Resveratrol had to offer was to determine the correct dosage required to enjoy the benefits. Laboratory experiments had shown the need for large doses of Resveratrol in order to make it beneficial, yet the quantities consumed were tiny. This inconsistency in the argument was actually termed as the “Resveratrol Paradox”. However, thanks to the recent research from Scripps, solutions to this paradox seem to have finally been found.
The confusing results led people to challenge the French Paradox itself and the evidence of fraud tainted some of the Resveratrol research. However, despite these problems, Resveratrol continued to show amazing results when used in mice or on humans and it was shown to actually offer significant benefits. One trial showed it improved blood circulation in the human brain and helped to fight Alzheimer’s, another study found that it triggers a stress response system by targeting the tRNA synthetases enzyme and other studies found that it offered antioxidant and anti-inflammatory properties to the skin. The Schimmel lab finally cleared the mystery by confirming that Resveratrol was actually beneficial for the human body because there exists a molecular resemblance between tyrosine and the chemical and this allows it to easily fit into the TyrRS binding pockets that tryrosine tends to occupy. The resulting TyrRS/ Resveratrol complex migrates into the cell nucleus and attaches itself to the PARP-1 protein, a protein that is already known to be involved in the stress response system of the human body.
According to the research conducted by Scripps, Resveratrol triggers a response system that has been deeply imbibed into the genes and dates back to hundreds of millions of years ago. Sajish, the first author of the study, mentions that it is conceivable that moderate amounts of red wine would actually offer enough Resveratrol to evoke the protective effects that can be found using this pathway. Derek Lowe, a medicinal chemist, also found the study to be fairly convincing.