Tag Archives: Resveratrol Benefits

Japanese Knotweed

Although Japanese knotweed may sound like something you’d want to ignore, this plant is quite incredible. Japanese knotweed contains high concentrations of resveratrol, and many resveratrol supplements use Japanese knotweed over grapes for the production and formulation of these pills. Keep reading to learn what Japanese knotweed is, what its relationship to resveratrol is and how resveratrol provides the body with health benefits.

Japanese Knotweed

What is Japanese Knotweed?
Japanese knotweed is a plant native to China, North and South Korea and Japan. Originally, it was introduced as an ornamental plant with its wide oval-shaped leaves and hollow stems, but it has since been used for a wide range of purposes. Japanese knotweed is not cultivated around the world and can be found growing along the rivers of the United States and Canada. For centuries, Japanese knotweed was used as a laxative, which led to the discovery of its medicinal properties. Although Japanese knotweed is edible, and is said to have a taste similar to rhubarb, many people only use Japanese knotweed to harvest its incredible antioxidant, resveratrol.

Japanese Knotweed and Resveratrol
Many people associate resveratrol with red wine, and there is a good reason. The skin of grapes is a well-known source of resveratrol, but Japanese knotweed is a more potent source of resveratrol. Resveratrol is a potent flavonoid and is praised for its many health benefits. While many assume that resveratrol supplements are made primarily using grapes, Japanese knotweed is the preferred source for many manufacturers. Part of the reason that Japanese knotweed is preferred to the skin of grapes is that this plant can be grown year-round and is more consistent with its levels of resveratrol, making it a more effective source of resveratrol.

Benefits of Resveratrol
The health benefits of resveratrol are wide-ranging and research regarding this antioxidant is constant. Three of the most important health benefits of resveratrol include:

  • Anti-Aging – Resveratrol is well-known for its anti-aging properties and its use for this purpose is common. As an antioxidant, resveratrol fights harmful free radical damage and can be incredibly beneficial when applied topically. However, your skin is not the only area of your body that resveratrol can aid with regards to aging. Resveratrol affects the activity of sirtuins, which are enzymes in your body and this interaction has a positive effect on age-related diseases like type 2 diabetes, Alzheimer’s and cardiovascular diseases.
    Cancer Prevention – Perhaps most miraculously, resveratrol has been shown to effectively reduce tumors in size and weight, and in a study involving mice, it was also shown to inhibit lung metastasis with highly metastatic lung carcinoma. The cancer-fighting benefits of resveratrol continue to be studied.
  • Weight Loss – Health experts note that calorie restriction is important to losing and maintaining a healthy body weight. Resveratrol has been shown to have effects similar to following a calorie-restricted diet, thus helping people to lose weight. Resveratrol is currently the most potent compound that activates SIRT1, which is what produces the calorie restriction effects. Of course, resveratrol should not be the only thing one relies on to lose weight, but adding a resveratrol supplement can help significantly when combined with proper nutrition and exercise.

Japanese knotweed is one of the best sources of resveratrol, and is used in the formulation of many resveratrol supplements. Adding resveratrol to your diet can help delay the effects of aging, both physical and mental, help you lose and maintain weight and may be a powerful anti-cancer agent. Taking a resveratrol supplement can be an easy and effective way to maintain optimal health.

Vine Vera Reports: Resveratrol As Immune Booster – Vine Vera Reviews

Vine Vera came across a study conducted by researchers at the Linus Pauling Institute, Oregon State University. According to the results of this study, resveratrol (a compound found in red wine and in the skin of red grapes) and pterostilbene (a compound found in blueberries) stood out because of their ability to boost the human innate immune system. Both compounds worked in combination with vitamin D and they had a tremendous impact in raising the expression of the CAMP gene, a gene that is involved with the immune functions of the body. The research was published in the Molecular Nutrition and Food Research Journal and has been supported by the National Institutes of Health.

Immune system at work with help from Resveratrol Despite the interest in stilbenoids like pterostilbene and resveratrol, their bioavailability is in doubt. The researchers believe that some of their applications may even offer topical solutions to improve the barrier defense in infections and wounds. Stilbenoids are basically compounds that are produced by plants as a means of fighting infection. This research goes on to show that combining stilbenoids with vitamin D will have a better impact than any of these compounds would offer individually.

The study analyzed 446 different compounds for their ability to boost the immune system. According to Adrian Gombart, an associate professor at the OSU College of Science, these two compounds stood out from among the hundreds that were tested. He mentions that their synergy with vitamin D in terms of increasing the expression of the CAMP gene was intriguing and significant.

Resveratrol has already been subjected to all sorts of studies to examine its possible benefits, and it seems as if the compound keeps coming up with new benefits every now and then. From fighting cancer and improving cardiovascular health to protecting the skin and reducing inflammation, this compound really has it all.

The CAMP gene has also been subjected to all sorts of studies because of the fact that it is known to play a huge role in the innate immune system, also known as the first line of defense of the human body when it comes to combating bacterial infection. The response of the immune system is particularly important in the modern world as a number of antibiotics are beginning to lose their effectiveness. The regulation of this gene by vitamin D was discovered by Gombart, but researchers are still finding out more about how compounds affect immune functions.

The research conducted by Oregon State University scientists is the first one to show a proper synergy with vitamin D that helped in increasing the CAMP gene by several times. However, all findings were made using laboratory cell cultures.  Experts state that it is not necessary that dietary intake of these compounds would lead to similar results. That being said, this study certainly makes the potential that certain foods have to offer all the more interesting.

More research is required to understand things better. Continued research could also offer a better understanding of how nutrition and diet affect the immune system. This is expected to lead to the development of natural compounds that can work wonders in boosting the innate immune response.

Can Resveratrol Help Diabetes? Vine Vera Reviews

Diabetes medical research includes Resveratrol

Resveratrol, your friendly red wine component, has been attributed to all sorts of wonderful things like protection from free radical damage and antioxidant properties to anti-inflammatory properties and health benefits. Resveratrol is usually found in red wine and in the skin of red grapes and it is commonly derived from a plant called Japanese knotsweed as well. Previous studies have already found Resveratrol to offer all sorts of health benefits. Vine Vera reviewed one study that was conducted in the year 2012 which showed that Resveratrol helped in balancing issues when administered in a group of mice. Another study that was conducted in the year 2011 also showed that Resveratrol countered the effects of inability and helped the body to stay physically active. Other studies on Resveratrol have found that the compound works wonders in protecting the body from obesity and also reduces the risks of blood clotting. It now seems that Resveratrol might also be beneficial in helping patients suffering from Type 2 diabetes mellitus.

This revelation was made by a group of researchers in a review that was published in the Molecular Nutrition and Food Research Journal. According to this review, Resveratrol was found to be extremely effective in treating the Type 2 diabetes mellitus in animal models. The evidence from the study also suggests that Resveratrol might actually benefit Type 2 diabetes as well. This review that was conducted by the researchers is actually based on a group of studies that examined a total of 196 type 2 diabetes mellitus patients. These studies had found Resveatrol to act as an adjunct to pharmaceutical intervention of the Type 2 diabetes mellitus. The studies had also shown Resveratrol to be very effective in lowering hemoglobin A1c, systolic blood pressure and creatinine concentrations.

That being said, the studies didn’t find Resveratrol to have an effect on low density lipoprotein cholesterol, fasting glucose, high density lipoprotein cholesterol, diastolic blood pressure, triglycerides, insulin and homeostatic model assessment of insulin resistance. The studies didn’t find any adverse effects of Resveratrol in the Type 2 diabetes mellitus patients either.

Vine Vera reviewed another study that was published in the Natural Medicine Journal. The researchers associated with this study used a placebo-controlled, double-blind trial to examine the effects of Resveratrol in lowering the blood glucose and its related outcomes. The trial focused on 66 participants (33 men and 33 women) who had Type 2 diabetes. All subjects were assigned to receive 500mg of Resveratrol or placebo tablets for a period of 45 days. Once the outcomes were assessed, it was determined that Resveratrol treatments significantly decreased the systolic blood pressure, the fasting blood glucose, insulin as well as hemoglobin Ac1. No adverse effects of Resveratrol administration were found.

Moreover, Resveratrol is also known to help in preventing insulin resistance, a condition that makes the body less sensitive to the effects of insulin. Insulin resistance has already been termed as a precursor to diabetes. A number of rodent studies further confirmed that Resveratrol can help against the effects of an unhealthy lifestyle and bring about an increased longevity. Mice with a high-calorie diet actually managed to live longer after being given Resveratrol supplements.

Vine Vera Reports: Studies Show that Resveratrol Protects DNA – Vine Vera Reviews

DNA strands affected by Resveratrol

Resveratrol, the red wine antioxidant that is known to offer wonderful solutions for your skin care, has also shown to activate an ancient stress response mechanism in your cells that allow them to guard themselves against DNA damage. Vine Vera came across a study that was conducted by the scientists from the Scripps Research Institute, which explained the health benefits that have attributed to Resveratrol, a compound that is found in the skin of red grapes and in red wine.

According to the study, lower levels of Resveratrol are more than sufficient to activate the stress response system in your skin. These levels are far lower than what was previously believed and the study itself helps to clear up a lot of mystery that initially surrounded Resveratrol and the benefits that it had to offer.

Vine Vera found this study published in the Nature Journal. The study re-builds on the recent research conducted by the Scripps Research Institute, which had discovered the existence of unique mechanisms that were associated with the enzymes being studied. Resveratrol has already been attributed to the famous “French Paradox”. According to this paradox, people in France enjoy a lower cardiovascular disease rate despite their high saturated fat diet. One of the many problems in discovering the benefits that Resveratrol had to offer was to determine the correct dosage required to enjoy the benefits. Laboratory experiments had shown the need for large doses of Resveratrol in order to make it beneficial, yet the quantities consumed were tiny. This inconsistency in the argument was actually termed as the “Resveratrol Paradox”. However, thanks to the recent research from Scripps, solutions to this paradox seem to have finally been found.

The confusing results led people to challenge the French Paradox itself and the evidence of fraud tainted some of the Resveratrol research. However, despite these problems, Resveratrol continued to show amazing results when used in mice or on humans and it was shown to actually offer significant benefits. One trial showed it improved blood circulation in the human brain and helped to fight Alzheimer’s, another study found that it triggers a stress response system by targeting the tRNA synthetases enzyme and other studies found that it offered antioxidant and anti-inflammatory properties to the skin. The Schimmel lab finally cleared the mystery by confirming that Resveratrol was actually beneficial for the human body because there exists a molecular resemblance between tyrosine and the chemical and this allows it to easily fit into the TyrRS binding pockets that tryrosine tends to occupy. The resulting TyrRS/ Resveratrol complex migrates into the cell nucleus and attaches itself to the PARP-1 protein, a protein that is already known to be involved in the stress response system of the human body.

According to the research conducted by Scripps, Resveratrol triggers a response system that has been deeply imbibed into the genes and dates back to hundreds of millions of years ago. Sajish, the first author of the study, mentions that it is conceivable that moderate amounts of red wine would actually offer enough Resveratrol to evoke the protective effects that can be found using this pathway. Derek Lowe, a medicinal chemist, also found the study to be fairly convincing.