Tag Archives: INGRIDIENTS

These Ingredients Have Neuroprotective Benefits

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The central nervous system. That complex combination of the brain and the spinal chord, studied extensively, but understood only partially, constantly and mysteriously working to generate our movements, emotions, and desires. While a system so multifaceted can be so fascinating, it can also be extremely prone to malfunction. So many things can go wrong with a system so complicated, and unfortunately, our limited knowledge makes many of these difficult to treat. Neuropathic disorders and diseases continue to plague so many with so few solutions. That is why it is so important to protect ourselves against these disorders. Here are some ingredients with neuroprotective properties.

Glutamate Antagonists
Glutamate antagonists are the main treatment to used to control cell death in CNS disorders. Overexcitation of glutamate receptors causes calcium to increase, which has major consequences on the nerve. Glutamate antagonists inhibit the binding of glutamate to receptors and may help to avoid excitotoxicity. Some treatments with promising results include:

Estrogen
Estradiol helps to prevent excitotoxicity by inhibiting glutamate receptors, such as NMDA.

Ginsenoside Rd
Studies show that ginsenoside Rd may help to inhibit glutamate excitotoxicity, and has proven to be an effective and noninvasive treatment for ischemic stroke patients.

Progesterone
Progesterone has been shown to prevent secondary injuries in patients with stroke and traumatic brain injury.

Antioxidants
Antioxidants work to protect the body against oxidative stress, which is the main cause of neuron degradation. The effectiveness of antioxidants depends on the disease, gender, age, and ethnicity. Here are some of the most common antioxidants that have been shown to be beneficial in the reduction of oxidative stress in at least one neurodegenerative disease:

Fish Oil
Fish Oil contains n-3 polyunsaturated fatty acids that can prevent mitochondrial dysfunction and oxidative stress. It has potential to be neuroprotective and is the subject of many studies on its effects on neurodegenerative diseases.

Resveratrol
Resveratrol can prevent oxidative stress in disorders such as Alzheimer’s disease, multiple sclerosis, ALS, Parkinson’s disease and cerebral ischemia.

Vitamin E
Vitamin E has varying effects depending on the neurogenerative disease that is being treated. It is most effective On Alzheimer’s disease and may be somewhat beneficial in treating ALS, but it is ineffective in the treatment of Parkinson’s.

THC
THC can exert neuroprotective effects on ischemia of the brain by acting on glutamate receptors, cation channels, and other pathways,

Stimulants
Certain stimulants are neuroprotective in appropriate doses.

Nicotine
Nicotine has been shown to offset Parkinson’s disease in humans and monkeys. It is available in patch form.

Caffeine
Caffeine is protective against Parkinson’s disease and induces neuronal glutathione synthesis by promoting cysteine uptake.

Selegiline
This has been shown to delay early onset Parkinson’s disease by an average of nine months.

Are neuroprotective ingredients important to you? Which ones would you use? THC? Nicotine? Caffeine? Let us know what you think.